CerebraCell Supporting Scientific Articles

Characterized Bioelectric Signals by Means of Neural Networks and Wavelets to Remotely Control a Human-Machine Interface – Click Here

Ep:165 30 Days to a Better Brain | Dr. Amy Killen & Evan DeMarco – Click Here

Novel bifunctional cap for simultaneous electroencephalography and transcranial electrical stimulation – Click Here

The Anti-apoptosis Effect of Single Electroacupuncture Treatment via Suppressing Neuronal Autophagy in the Acute Stage of Ischemic Stroke Without Infarct Alleviation – Click Here

Magnetoelectric Materials for Miniature, Wireless Neural Stimulation at Therapeutic Frequencies – Click Here

Effects of Electric Cortical Stimulation (ECS) and Transcranial Direct Current Stimulation (tDCS) on Rats With a Traumatic Brain Injury – Click here

Placental umbilical cord blood transfusion in acute ischaemic stroke – Click Here

Biodegradable implant provides electrical stimulation that speeds nerve regeneration – Click Here

Muscle LIM Protein Is Expressed in the Injured Adult CNS and Promotes Axon Regeneration – Click Here

Can a hormone called klotho enhance cognition and hold off dementia? Yes, in mice, at least – Click Here

Attractive Guidance: How the chemokine SDF1/CXCL12 guides different cells to different locations – Click Here

Electrical Stimulation Enhances Migratory Ability of Transplanted Bone Marrow Stromal Cells in a Rodent Ischemic Stroke Model – Click Here

Electrical stimulation improved cognitive deficits associated with traumatic brain injury in rats – Click Here

Brain Implant for Paralysis Recovery – Click Here


Combination therapy of scalp electro-acupuncture and medication for the treatment of Parkinson’s disease: A systematic review and meta-analysis – Click Here

MSCs-Derived Exosomes and Neuroinflammation, Neurogenesis and Therapy of Traumatic Brain Injury – Click here

Stem cell stimulation improves stroke recovery – Click Here

Transcutaneous electrical stimulation on acupuncture points improves muscle function in subjects after acute stroke: a randomized controlled trial. – Click here

Electrical Stimulation Makes Old Brains Act Young Again – Click here

Noninvasive Brain Stimulation Turns Back Clock on Memory | The …


3 days ago – The approach temporarily improved the performance of older adults on memory tasks to be on par with people in their 20s.
Implantation of Brain-Derived Extracellular Matrix Enhances Neurological Recovery after Traumatic Brain Injury
Zap: How Electric Therapy Is Curing Navy SEALs of PTSD … And Could Remake Brain Science


Study: Electric Brain Stimulation Alleviates Some Disorders 

Inside the Science of an Amazing New Surgery Called Deep … 

Deep Brain Stimulation (DBS) Parkinsons Australia – YouTube 

What Electrical Stimulation Can Do For Stroke Recovery … 

Electrical stimulation as a means for achieving recovery of … 

Functional Electrical Stimulation for Stroke Rehab – YouTube 


Method of enhancing myogenesis by electrical stimulation … 

Electric currents applied to the brain can boost memory and … 

Retinal microvascular changes and subsequent vascular events …

Inhibition of Angiogenesis Mediated by Extremely Low-Frequency Magnetic Fields (ELF-MFs)




IGF-1 Controlled Release by Bioelectric Stimulation Provisional Patent …


Apr 2, 2016 – It has been demonstrated to be especially useful in brain regeneration. Some people have referred to IGF1 as the Fountain of Youth. We are ..

IGF-1 Reverses Aging and Heals damaged brain cells – Peptides

researchpeptides.com › Forum › Peptide Research › General Industry Discussion

Nov 12, 2015 – Growth Hormone Production and IGF1 The production of growth hormone is … HG has manifested the regeneration of damaged brain tissue.

effect of locally delivered igf-1 on nerve regeneration during … – NCBI


National Center for Biotechnology Information

by PJ Apel – ‎2010 – ‎Cited by 53 – ‎Related articles

The purpose of this study was to determine if locally delivered IGF1 would improve nerve regenerationand neuromuscular … These results show that aged regenerating nerve is sensitive to IGF1 treatment. ….. Brain Res Mol Brain Res. 1995 …

Role and Importance of IGF-1 in Traumatic Brain Injuries


by A Mangiola – ‎2015 – ‎Cited by 2 – ‎Related articles

Dec 24, 2014 – IGF1 plays an important role in brain growth and 

Insulin-like growth factor II stimulates motor nerve regeneration


Proceedings of the National Academy of Sciences of t…

by SL Near – ‎1992 – ‎Cited by 124 – ‎Related articles

factor H (IGF-ll) can stimulate motor nerve regeneration was … known as insulin-like growth factor II. (IGF-II) (10, 11) is one candidate diffusible substance. Brain.

Insulin-like growth factor (IGF-I) as a stimulator of regeneration in the …

https://www.researchgate.net/…/20436630_Insulin-like_growth_factor_IG ResearchGate

Brain Res 485: 102-108 on ResearchGate, the professional network for … The results suggest that IGF1 affects regeneration by local stimulation of the growing …

The Insulin-Like Growth Factor 1 Receptor Is Essential for Axonal …


by S Dupraz – ‎2013 – ‎Cited by 19 – ‎Related articles

Jan 18, 2013 – Axonal regeneration is an essential condition to re-establish functional neuronal … kinase (PI3K) signaling pathway, upon stimulation with IGF1. … The expression of IGF-1R is developmentally regulated in brain, reaching …

Hippocampal IGF-1 expression, neurogenesis and slowed aging …

link.springer.com/article/10.1007/s11357-006-9009-5 Springer Science+Business Media

by LY Sun – ‎2006 – ‎Cited by 13 – ‎Related articles

The Ames dwarf mouse is a murine model of circulating GH and IGF1 … 2002), whereas transgenic mice with ectopic brain expression of IGFBP-1, …. oligodendrocytes from injury and/or in promoting their regeneration following injury.

Postischemic IGF-1 Gene Transfer Promotes Neurovascular …


by W Zhu – ‎2009 – ‎Cited by 40 – ‎Related articles

Postischemic IGF1 Gene Transfer Promotes Neurovascular Regeneration after … There is great enthusiasm to repair the brain after stroke injury because .


Potential of Neural Stem Cell-Based Therapy for Parkinson’s Disease


by CH Chou – ‎2015 – ‎Related articles

Nov 3, 2015 – Neural stem cell (NSC) transplantation is an emerging strategy for …. distribution of the soluble factor stromal cell-derived factor-1 (SDF1), 

Development of stem cell-based therapy for Parkinson’s disease …


by F Han – ‎2015 – ‎Related articles

Parkinson’s disease Dopamine neuron Neural stem cell Human embryonic ….. al. were successful in replacing the PA6 stromal cells with growth factors SDF1, …


Use of Genetically Modified Mesenchymal Stem Cells to Treat …



by RD Wyse – ‎2014 – ‎Cited by 23 – ‎Related articles

Jan 23, 2014 – Abstract: The transplantation of mesenchymal stem cells (MSCs) for treating … Keywords: mesenchymal stem cells; genetic engineering; Parkinson’s; … factor-1 (SDF1), which is expressed in areas of inflammation in the brain …

Role of the SDF-1-CXCR4 axis in stem cell-based therapies for …

https://www.researchgate.net/…/41406917_Role_of_the_SDF1-CXCR4_a… ResearchGate

Role of the SDF1-CXCR4 axis in stem cell-based therapies for ischemic … Neuron Development In Vivo to Improve Stem Cell Therapy in Parkinson’s Disease.

The neuroblast and angioblast chemotaxic factor SDF-1 (CXCL12 …


by JT Miller – ‎2005 – ‎Cited by 110 – ‎Related articles

In addition to targeting hematopoietic cells, the SDF1/CXCR4 system is also known to play a critical role in embryonic brain development and adult injury repair …

SDF-1:CXCR4 Axis Is Fundamental for Tissue Preservation and Repair


National Center for Biotechnology Information

by MS Penn – ‎2010 – ‎Cited by 23 – ‎Related articles

Aug 13, 2010 – Further demonstrating the importance of the SDF1 in tissue repair, … heart and brain, up-regulation of the SDF1:CXCR4 axis is a fundamental …

Neural Regeneration – Page 226 – Google Books Result


Kwok-Fai So, ‎Xiao-Ming Xu – 2015 – ‎Science

KLF family members regulate intrinsic axon regeneration ability. … Brain Res Mol Brain Res 1994;24:43–54. … [232] Yin Y, Li Y, Cen L-P, Gilbert H-Y, Cui Q, Benowitz L. Stromal cellderived factor-1 (SDF1) contributes to inflammation-induced …

New Insight Into How The Brain Regenerates After Stroke …


Science Daily

Dec 23, 2006 – His lab studies the mechanisms of brain repair and the recovery of function … “TheSDF1 and Ang1 proteins are what link the two processes of …

Regeneration of Neuronal Cells following Cerebral Injury – FullText …


by T Dailey – ‎2013 – ‎Cited by 6 – ‎Related articles

Jul 8, 2013 – Department of Neurosurgery and Brain Repair, University of South Florida … When SDF1is active, HSCs cross the endothelial blood-BM barrier and … factor markedly improved stroke recovery in the animal models [16].

A Neurovascular Niche for Neurogenesis after Stroke

www.jneurosci.org/content/26/50/13007.abstract The Journal of Neuroscience

by JJ Ohab – ‎2006 – ‎Cited by 599 – ‎Related articles

Dec 13, 2006 – Furthermore, SDF1 and Ang1 promote post-stroke neuroblast … These experiments define a novel brain environment for neuronal regeneration after stroke and … and neurogenesis during functional recovery from brain injury.

UCLA Study Identifies Cellular Cues for Stroke Recovery | UCLA


University of California, Los Angeles

Jan 4, 2007 – When a stroke strikes, the supply of blood to the part of the brain … cues are necessary for this process of regeneration andmigration to take place. … stromal-derived factor 1 (SDF1) and angiopoietin 1(Ang1) — given off by …

Frontiers | Neurorestorative Therapy for Stroke | Frontiers in Human …


by J Chen – ‎2014 – ‎Cited by 35 – ‎Related articles

Stroke is one of the leading causes of mortality, long-term disability, and …. the adult CNS is critical tobrain repair processes after stroke (Hou et al., 2008). …. Neuropilin-1 (Nrp-1), NO, SDF1, and VEGF may maximize recovery (Madri, 2009).


Hepatocyte growth factor, a versatile signal for developing neurons …

www.nature.com › Journal home › Archive › Table of Contents › Review


by F Maina – ‎1999 – ‎Cited by 219 – ‎Related articles

Hepatocyte growth factor (HGF, also known as scatter factor) is one example of such a … It was later found to be involved in organ regeneration, angiogenesis and tumor … Both HGF and Met are expressed during brain development, and their …

Therapeutic potential of hepatocyte growth factor against cerebral …


by W Zeng – ‎2015 – ‎Cited by 1 – ‎Related articles

Dec 15, 2014 – Hepatocyte growth factor (HGF) is a potent pleiotropic cytokine that is involved in … in a variety of cells, and tissue regeneration in several organs (7–9). … be one of the most potent growth factors for treating brain ischemia.

Brain repair: cell therapy in stroke – NCBI – National Institutes of Health


National Center for Biotechnology Information

by D Kalladka – ‎2014 – ‎Cited by 32 – ‎Related articles

Feb 21, 2014 – In the animal models of stroke, both mesenchymal stem cells (MSCs) and neural stem cells (NSCs) improve functional recovery, and MSCs …. experimentally by extrinsic growth factors, likehepatocyte growth factor,22 and …

Angiogenesis, neurogenesis and brain recovery of function following …


National Center for Biotechnology Information

by Y Xiong – ‎2010 – ‎Cited by 167 – ‎Related articles

Traumatic brain injury and stroke are major causes of mortality and morbidity worldwide. … the repairand regeneration of injured brain tissue and functional recovery. ….. MSCs transferred with ex vivohepatocyte growth factor gene are more …

Therapeutic potential of hepatocyte growth factor against cerebral …


by W Zeng – ‎2015 – ‎Cited by 1 – ‎Related articles

Dec 15, 2014 – Hepatocyte growth factor (HGF) is a potent pleiotropic cytokine that is involved in cell … in a variety of cells, and tissue regeneration in several organs (7–9). … brain tissue of patients who had survived acute ischemic stroke for up to ….. XF: VEGF promotes angiogenesis and functionalrecovery in stroke rats.

Acute hepatocyte growth factor treatment induces long-term …

https://www.researchgate.net/…/49647093_Acute_hepatocyte_growth_fact… ResearchGate

Hepatocyte growth factor (HGF) is an interesting candidate for acute stroke … (5 μg) after a 45-minutestroke, with regard to brain injury and neurologic recovery. …… in biological procedures relating to development and regeneration [3] [4].

Regeneration of Neuronal Cells following Cerebral Injury – FullText …


by T Dailey – ‎2013 – ‎Cited by 6 – ‎Related articles

Jul 8, 2013 – Naritomi H, Krieger DW (eds): Clinical Recovery from CNS Damage. … Department of Neurosurgery and Brain Repair, University of South Florida …. as: hepatocyte growth factor (HGF), vascular endothelial growth factor, … For example, early increases (1 h after stroke) could increase blood-brain barrier …

Hepatocyte growth factor mediates mesenchymal stem cell-induced …



by L Bai – ‎2012 – ‎Cited by 150 – ‎Related articles

Apr 17, 2012 – They identify hepatocyte growth factor and its receptor cMet as critical for this effect. … neural stem cells and survival of newborn cells in a rat stroke model. … Expression of HGF and cMet in the developing and adult brain. … Hepatocyte growth factor promotes endogenous repair and functional recovery …

Growth Factors Released from Gelatin Hydrogel Microspheres …


by K Nakaguchi – ‎2012 – ‎Cited by 10 – ‎Related articles

Aug 9, 2012 – Hepatocyte growth factor (HGF)-containing microspheres increased the … release of growth factors holds promise for the clinical regeneration of … new neurons to the injured brain afterstroke in a mouse model. … After surgery, the animals were left on a heat mat and constantly monitored until recovery.


Tissue absence initiates regeneration through Follistatin-mediated …

https://www.researchgate.net/…/256614967_Tissue_absence_initiates_rege ResearchGate

Smed-follistatin inhibits Smed-Activin proteins to trigger regeneration specifically following ….. and did not regenerate a brain as assayed with an RNA probe for …

Follistatin-Like 1 Attenuates Apoptosis via Disco-Interacting … – Stroke

stroke.ahajournals.org/content/45/10/3048.full Stroke

by X Liang – ‎2014 – ‎Cited by 3 – ‎Related articles

Aug 19, 2014 – Recombinant FSTL1 reduced brain infarction and improved … The incision was closed with sutures, and the rat was allowed to recover.

[Expression of follistatin, activin A and BMP-4 in rats with … – JoVE


Journal of Visualized Experiments

Oct 25, 2014 – Here we describe a protocol that has been optimized to recover these discs … At present, two major types of ischemic stroke models have been …


Scientists identify main component of brain repair after stroke …


National Institutes of Health

Oct 27, 2015 – Scientists identify main component of brain repair after stroke … “We found thatregeneration is a unique program in the brain that occurs after …

Biologists have found a gene that controls brain repair | ExtremeTech

www.extremetech.com › Extreme


Oct 29, 2015 – Control of a single gene can stimulate partial regeneration after a damaging stroke, in both live mice and cultured human …




by SS Mukerji – ‎2009 – ‎Cited by 1 – ‎Related articles

Oct 17, 2008 – administration of activin A prior to stroke onset protected against ….. information on circuit reorganization and repair mechanisms …… growth and tubulogenic effects on endothelial cells necessary for hepatic regeneration.

Neuroregenerative strategies in the brain: emerging significance of …


Sep 24, 2008 – aNeurogenesis and Brain Repair Group, Neurobiology Program, …. andneuroregeneration in animal models of brain injury and stroke (Chang et al. 2003 … BMP receptor II (BMPRII), activin receptor IIA (ActRIIA), and activin …

The roles of activins in repair processes of the skin and the brain.

www.ncbi.nlm.nih.gov/…/11451588 National Center for Biotechnology Information

by B Munz – ‎2001 – ‎Cited by 50 – ‎Related articles

Mol Cell Endocrinol. 2001 Jun 30;180(1-2):169-77. The roles of activins in repair processes of the skin and the brain. Munz B(1), Tretter YP, Hertel M, Engelhardt …

Activin: a novel player in tissue repair processes. – NCBI

www.ncbi.nlm.nih.gov/pubmed/9987674 National Center for Biotechnology Information

by G Hübner – ‎1999 – ‎Cited by 58 – ‎Related articles

Recent studies have demonstrated a strong expression of activin in repair … the skin, the lung, the intestine, the cardiovascular system, and even the brain.

Activin plays a key role in the maintenance of long-term memory and …


by H Ageta – ‎2010 – ‎Cited by 25 – ‎Related articles

Thus, the level of activin in the brain during the retrieval phase plays a key role in the … 1A), which eliminates the possibility that neuronal damage occurred.


Roles for VEGF in Brain Repair


Home · Organizations. Roles for VEGF in Brain Repair Conference Paper uri icon. Overview. authors. Janette M Krum. publication date. 2004. presented at event.

Role of vascular endothelial growth factor in neuronal DNA damage …


National Center for Biotechnology Information

by ZJ Yang – ‎2002 – ‎Cited by 84 – ‎Related articles

Oct 15, 2002 – … growth factor in neuronal DNA damage and repair in rat brain following a … Western blot analysis further illustrated that VEGF induction was …

JCI – VEGF: a critical player in neurodegeneration


Journal of Clinical Investigation

by E Storkebaum – ‎2004 – ‎Cited by 178 – ‎Related articles

VEGF can also have favorable effects on the recovery of an ischemic brain insult. …. DNA damage andrepair in rat brain following a transient cerebral ischemia.

Neurotrophic Effects of Vascular Endothelial Growth Factor on …


The Journal of Neuroscience

by JM Rosenstein – ‎2003 – ‎Cited by 191 – ‎Related articles

for the first time, that VEGF is directly neurotrophic to CNS neurons in culture. …… revascularization and astroglial proliferation: roles for VEGF in brain repair.

VEGF overexpression induces post-ischaemic neuroprotection … – Brain



by Y Wang – ‎2005 – ‎Cited by 219 – ‎Related articles

Oct 27, 2004 – In fact, early post-ischaemic systemic delivery of VEGF increased blood–brain barrier (BBB) leakage and tissue damage after stroke, while …

Research progress of VEGF and brain injury repair mechanism


Vernacular Title: VEGF与颅脑损伤修复机制的研究进展. Author: Keywo

Electrical Stimulation 

Stimulating brain with electricity ‘boosts stroke recovery’ – BBC News



Mar 17, 2016 – Stimulating the brain with electrical current can help improve recovery after a stroke, research from the University of Oxford suggests.

“Micro-Current Biotech” Therapy for Stroke Rehabilitation from WWC …



Dec 15, 2015 – Micro-Current Biotech” Therapy for Stroke Rehabilitation from WWC Probiotics, …TENS and later on MENS are used to take away pain of Diabetic … talk about strategy as if it’s some kind of high-brain scientific methodology.

Post-Stroke Treatment with Microcurrent and Acupuncture – YouTube



May 29, 2013 – Uploaded by MicroLightVideos

Post-Stroke Treatment with Microcurrent and Acupuncture … of microcurrenttherapy, Microlight therapy …

Electrical brain stimulation could support stroke recovery: Hand and …


Science Daily

Mar 16, 2016 – Applying an electric current to the brain can help recovery from stroke, Oxford University researchers have found. A team from Oxford’s Nuffield …

Electrical Stimulation Elicits Neural Stem Cells Activation: New … – NCBI


National Center for Biotechnology Information

by Y Huang – ‎2015 – ‎Cited by 1 – ‎Related articles

Oct 19, 2015 – Keywords: electrical stimulation, neural stem cells, activation, … that endogenous NSCs can be a potential therapy for brain tissue repair.

Edmonton Neurotherapy: Non-Invasive Brain Stimulation …


Information on non-invasive brain stimulation/neuromodulation technologies … for medical devices using microcurrent levels of electrical stimulation across the ….. within stroke rehabilitationprograms to enhance motor function re-learning.

Directing migration of human stem cells with electric fields …


California Institute for Regenerative Medicine

We will combine the electric stimulation with other treatment to establish a potent and … We aim to guide human stem cells to repair diseased or damaged tissues. … electric fields in the brain, which may guide migration of neural stem cells.

Electrical Stimulation of the Brain Boosts Birth of New Cells


Society for Neuroscience

Animal study suggests deep brain stimulation improves memory … and Science, an expert on stem cells and brain repair who was unaffiliated with the study.

Developing stem cell-based therapies for neural repair:


Clare Parish, ‎Lachlan Thompson – 2015

While the link between electrical stimulation of the human brain and neurogenesis awaits investigation, a phase I clinical trial assessing the effect of DBS .

Targeted brain stimulation aids stroke recovery in mice, scientists find …


Stanford University School of Medicine

Aug 18, 2014 – Animal studies have indicated that electrical stimulation of the brain can improve … However, “existing brain-stimulation techniques activate all cell types in the …. Neural stem cellshelped repair stroke damage in rats’ brains.

Less-invasive method of brain stimulation helps patients with …


Science Daily

Oct 16, 2012 – Electrical stimulation using extradural electrodes—placed … meaningful benefits for patients with Parkinson’s disease, according to new research.

FDA approves the treatment of brain tumors with electrical fields



Feb 13, 2012 – The promising new non-invasive treatment by Novocure uses “Tumor Treating Fields” (NovoTTF) to treat cancerous growths and is now …

Electrical Scalp Device Can Slow Progression of Deadly Brain Tumors …


The New York Times

Nov 15, 2014 – An electrical device glued to the scalp can slow cancer growth and prolong … with the deadliest type of brain tumor, glioblastoma, researchers have found. … So far, Novocure has been providing it free to patients without …

Bill Doyle: Treating cancer with electric fields | TED Talk | TED.com




With his company Novocure, Bill Doyle works to bring breakthrough medical …. Please show me any 2 brain …

This Electric Helmet Looks Goofy But It Zaps Deadly Brain Cancer



May 22, 2014 – This Electric Helmet Looks Goofy But It Zaps Deadly Brain Cancer · Sarah Zhang … It Zaps Deadly Brain Cancer. Images courtesy of NovoCure.

Electroacupuncture preconditioning reduces cerebral ischemic injury …


by JH Kim – ‎2013 – ‎Cited by 23 – ‎Related articles

In addition, we investigated whether the expression of brain-derived … The expression of BDNF proteinincreased significantly from 6 h, reaching a plateau at 12 h … Focal cerebral ischemia Electroacupuncture BDNF SDF-1α Preconditioning … of 1 mA and a frequency of 2 Hz for 20 min using Grass S88 electro stimulator …


Breakthrough in stem cell treatment for Parkinson’s – Medical News …


Medical News Today

 Rating: 4.7 – ‎10 votes

Nov 7, 2014 – Researchers say it is possible to make dopamine

Fetal cells injected into a man’s brain to cure his Parkinson’s | New …


New Scientist

May 26, 2015 – An experimental Parkinson’s treatment abandoned in the 1990s has been … and couldrestore a person’s control of their movement

Cell replacement therapy for Parkinson’s disease – ScienceDirect



by R Wijeyekoon – ‎2009 – ‎Cited by 54 – ‎Related articles

Of these embryonic stem cells and induced pluripotent stem cells seem the most …. has always been attractive for the treatment of any disorder including Parkinson’s … This patient had derived some clinical benefit from the graft for ∼ 4 years … functional recovery following intra-striatal transplantation of carotid body cell …

Neural stem cell transplants aid traumatic brain injury recovery …


Apr 19, 2016 – Traumatic brain injury (TBI) is a major cause of mortality and morbidity, often causing lifelong disability for those who survive. When researchers …

Stem cells help repair traumatic brain injury by building ‘biobridge …


Science Daily

Oct 3, 2013 – Stem cells help repair traumatic brain injury by building ‘biobridge’ … in the brain in need of repair, helping promote functional recovery from …

Can Stem Cells Help Restore Brain Function After Traumatic Injury …



Nov 7, 2014 – Research using human neural stem cells (hNSCs) is showing promise. … stem cells(hNSCs) to promote recovery of neural function after injury.

Stem cell therapy shows promise in repairing brain damage even …


Stem cell therapy shows promise in repairing brain damage even hours after stroke … ensure complete recovery for stroke patients poses an extreme challenge, …

Siddharthan Chandran: Can the damaged brain repair itself? – TED.com




Feb 24, 2014

After a traumatic brain injury, it sometimes happens that the brain can repairitself, building new brain cells …

Electrical stimulation of cerebellar fastigial nucleus promotes the …



by B Liu – ‎2012 – ‎Cited by 11 – ‎Related articles

This study focused on the effects of electrical stimulation of cerebellar fastigial nucleus on the expression of growth arrest and DNA damage inducible gene β.

These results suggest that FN electrical stimulation can promote the expression of Gadd45β and motor function recovery after focal cerebral ischemia.

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Sujet : Add to CerebraCell Related Articles on Web Site Page

Neuronal apoptosis in cerebral ischemia/reperfusion area following …


Neural Regeneration Research

by J Liu – ‎2014 – ‎Cited by 12 – ‎Related articles

May 29, 2014 – Results from the electrical stimulation group revealed that rats exhibited a …. TheDNA repair proteins, Ku70 and Ku80, are DNA-binding regulatory … Cytoplasmic Ku70 is involved in the control of cell apoptosis, specifically Bax-mediated apoptosis . …. Ku70 and Bax expressionfollowing fastigial nucleus

Neuronal apoptosis in cerebral ischemia/reperfusion area following …


Neural Regeneration Research

by J Liu – ‎2014 – ‎Cited by 12 – ‎Related articles

May 29, 2014 – Results from the electrical stimulation group revealed that rats exhibited a …. TheDNA repair proteins, Ku70 and Ku80, are DNA-binding regulatory … Cytoplasmic Ku70 is involved in the control of cell apoptosis, specifically Bax-mediated apoptosis . …. Ku70 and Bax expressionfollowing fastigial nucleus

Biologists show bioelectrical signals control tumors arising from …


May 28, 2014 – “These distant bioelectric signals suppressed tumor growth, despite the cells’ … Prior News New fNIRS -FD instrument can identify affected areas of brain … Tecentriq drug gets FDA approval to treat urothelial carcinoma.

Electrical brain stimulation could support stroke recovery

medicalxpress.com › Neuroscience

Mar 16, 2016 – Applying an electric current to the brain can help recovery from … plus anodal tDCS compared to motor rehabilitation plus sham treatment.


 2014 Feb 11;94(5):382-5.      https://www.ncbi.nlm.nih.gov/pubmed/24746089

[Effects of low-frequency electrical stimulation of hippocampus on the expression of GABAA receptor α1 and β2 subunits in kainate-kindled rats].





To explore the effects of low-frequency electrical stimulation (LFS) of hippocampus on the expression of GABAA receptor α1 and β2 subunits in the kainite (KA)-kindled rats and explore its underlying rescue mechanism for temporal lobe epilepsy.


The SD rats were divided into 4 groups (n = 10):control group:no operation; epilepsy group:KA was stereotactically injected into rat hippocampus to establish KA-kindled model; sham-LFS group:only implanting of electrodes into hippocampus without LFS; LFS group:KA-kindled model with LFS. Then hippocampal tissues were collected and their expressions of GABAA receptor α1 and β2 subunits measured by immunohistochemistry, quantitative-polymerase chain reaction (q-PCR) and Western blot.Nissl staining was performed to detect the number of damaged hippocampal neurons.


There were significant decreases of GABAA receptor α1 and β2 subunits in kindled hippocampus (P < 0.01). LFS resulted in an effective rescue, but failed to reach normal levels. The damaged neurons could not be reversed according to Nissl staining.


The hippocampal application of LFS may protect against seizures by modulating the expressions of α1 and β2 GABAA receptor subunits.


Electroacupuncture Treatment Improves Learning-Memory Ability – NCBI



National Center for Biotechnology Information

by J Jiang – ‎2015 – ‎Cited by 2 – ‎Related articles

Mar 3, 2015 – Electroacupuncture Treatment Improves Learning-Memory Ability and Brain Glucose Metabolism in a Mouse Model of Alzheimer’s Disease: …

Electroacupuncture Treatment Improves Learning … – ResearchGate

https://www.researchgate.net/…/274262088_Electroacupunctu  ResearchGate

Official Full-Text Publication: Electroacupuncture Treatment Improves Learning-Memory Ability and Brain Glucose Metabolism in a Mouse Model of Alzheimer’s …

New Alzheimer’s treatment fully restores memory function – ScienceAlert


Mar 18, 2015 – Of the mice that received the treatment, 75 percent got their memories back. … for Alzheimer’s – a disease that affects 343,000 people in Australia, and 50 … against bacteria, and stimulate the brain’s microglial cells to activate.

Acupuncture Rejuvenates Alzheimer’s Disease Patients – HealthCMi


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—–Original Message—–
From: Howard Leonhardt <hleonhardt@aol.com>
To: brian <brian@fizzpopmedia.com>
Cc: santoshkesari <santoshkesari@gmail.com>; lmiller1429 <lmiller1429@gmail.com>; garrett <garrett@neu.fit>; robertthouser88 <robertthouser88@gmail.com>; bburton <bburton@leonhardtventures.com>; alex4calx <alex4calx@gmail.com>; ppatton231 <ppatton231@verizon.net>; jdonofrio <jdonofrio@restoremed.com>; laurie.chaikin <laurie.chaikin@gmail.com>; larry <larry@fdadeviceexpert.com>; kelsieleonhardt <kelsieleonhardt@gmail.com>; pnrmn <pnrmn@comcast.net>; nwkearley <nwkearley@gmail.com>
Sent: Wed, May 15, 2019 12:17 pm
Subject: Potential easy to implement CerebraCell study to repeat this same study this time with electroacupuncture > Add to CerebraCell Related Articles > Scalp Acupuncture Restores Function After Stroke

Dear Santosh, Garrett, Robert, Les, Brett, Alex, Laurie, 
I would like to have our CerebraCell team look into repeating this study this time with elecroacupuncture with our bioelectric signaling sequences especially the klotho, SDF1, PDGF and IGF1 signals.  
This should be a low regulatory hurdle.  
Kindest Regards, 



Scalp Acupuncture Restores Function After Stroke

  04 AUGUST 2015
Scalp acupuncture enhances neurologic repair and reduces cerebral edema due to an intracerebral hemorrhage (ICH), a type of stroke. Researchers conducted a laboratory experiment on laboratory rats and discovered that acupuncture improves neurologic functions following an ICH. Head and scalp acupoints are located on this acudoll. Additionally, a biochemical analysis reveals that acupuncture regulates expression of MMP-9 (matrix metallopeptidase), an enzyme that breaks down extracellular matrix and is involved in tissue remodeling.
Functional improvements included significant enhancements of limb bending, ability to stand, performance of voluntary movements, and a reduction of paralysis. The procedure used to achieve the clinical results was the application of the threading needle technique combined with scalp acupuncture. Acupuncture point Baihui (GV20) was connected to Xuanli (GB6) using the threading technique. The procedure was tested against a control group and demonstrated significant clinical efficacy in cerebral edema reduction, functional improvements, and regulation of MMP-9.
Acupuncture enhanced resorption of blood stasis due to internal bleeding. Combined with acupuncture’s ability to regulate of MMP-9, the researchers suggest that these objective results contributed to the enhanced neurologic functional recovery and reduction of internal bleeding. The researchers gave a brief summary for the basis of the investigation citing prior research. 
Wang Qiang et al. concluded that brain internal bleeding leads to toxic reactions and therefore cerebral edema. GB6 is located on the side of the head. Hence, controlling toxic reactions and cerebral edema is a key factor in the treatment of brain internal bleeding. Yin Nina et al. concluded that pain reduction on patients has a direct impact on the reduction of cerebral edema and controlling MMP-9 expression. Huang Wei has also concluded that cerebral edema can be ameliorated through controlling MMP-9 expression. Prior research demonstrates that acupuncture regulates MMP-9 expression in a homeostatic manner, both in cases of upregulation and downregulation as required by differing medical disorders.
The acupuncture points chosen for the study are on the scalp. GV20 is referred to as Baihui, which is translated as hundred meetings. Located at the vertex, this acupoint is indicated for the treatment of stroke and related conditions including headache, heaviness of the head, dizziness, hypertension, hemiplegia, loss of consciousness and blindness. This acupoint is also used in the treatment of fright, palpitations, poor memory, irritability, and disorientation. GV20 is closely associated with benefitting the brain and is known as a point of the sea of marrow. GV20 was threaded to acupoint GB6. This gallbladder channel acupoint is known as Xuanli, which translates into suspended hair. The acupoint is located within the hairline on the temporal aspect of the scalp.
In related research, Wang et al. conclude that scalp acupuncture combined with local acupuncture to the hand restores hand function. In a human clinical trial, the researchers achieved an 85% total effective rate for patients recovering hand functionality after a stroke. Given this investigation and the prior research, scalp acupuncture presents as a central component to functional recovery after a stroke.
Li Xueyan, Zhang Liang. Experimental Study on Neuroprotective Effects of Acupuncture and Intervention on MMP-9 Expression in Rats with Intracerebral Hemorrhage, Information on Traditional Chinese Medicine, 2015 (4).
Wang, D. Y., Wang, F. F., Li, X. Y. & Zhao, X. (2014). Effect of Cluster Needling of Scalp Acupuncture Combined with Hand Penetration Acupuncture on the Recovery of Hand Function after Stroke. Journal of Clinical Acupuncture and Moxibustion (11).
Lu. B. W. & Chen. H. B. (1996). Normal Human Anatomy [M]. Ha Er Bin: Heilongjiang Scientific Education Publisher (222).

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