1963

The first to use chronic depth stimulation as a therapy in motor disorders was Natalia Petrovna Bekthereva, neuroscientist at the Institute of Experimental Medicine and the Academy of Medical Sciences in Leningrad. In 1963 she published a work on the use of multiple electrodes implanted in sub-cortical structures for the treatment of hyperkinetic disorders (Bekthereva et al., 1963). However, since her papers were written in Russian, her works were not well known around the world. In her “therapeutic electro-stimulation,” as she named this method, she used “electric stimulation with high-rate pulses of suprathreshold current,” achieving excellent results (Bekthereva et al., 1975).

1999

Leonhardt research team collaborator Dr. Shinichi Kanno publishes in CIRCULATION the Journal of American Heart Association first paper on bioelectric limb regeneration via controlled expression of proteins such as VEGF.

2001

Leonhardt leads team that completes first ever non-surgical stem cell repair of human heart in The Netherlands with Dr. Patrick Serruys.   Team went on to complete, publish and present Pilot, Phase I, Phase II and Phase II/III study results working with 33 centers in the USA and 6 centers OUS.   84% of treated patients improved or did not decline.  Only 16% of treated patients declined.  69% of control or placebo patients in these same studies worsened in heart function.

2007

Howard Leonhardt and noted bioelectric regeneration research Dr. Jorge Genovese formerly from the University of Utah join forces as co-inventors and begin filing numerous patent application claims together for bioelectric based organ regeneration and recovery.

2015

Dr. Giorgio Lofrese and colleagues in Italy publish on the importance of IGF-1 in brain injury recovery – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568328/

2016

Leonhardt and Genovese filed provisional patent application for bioelectric stimulation controlled release of IGF-1.

Leonhardt’s Launchpads Utah, Inc. with CerebraCell are accepted into the BioInnovations Gateway USTAR laboratory in Utah with access to over $30 million of research lab equipment and resources and subsidized research lab space.

CerebraCell Utah lab team lead by Michael Angerbauer tests out various brain helmet designs for brain stimulation.

Leonhardt and Genovese filed provisional patent application for CerebraCell “Brain Saving Helmet”.

Stanford team (not associated with CerebraCell) led by Dr. Gary Steinberg published landmark study demonstrating remarkable recovery of some brain stroke patients treated with modified stem cells.

CerebraCell announces collaboration with HeartScore to develop a total stroke management program.

CerebraCell presents at Neuro Tech Leaders Forum San Francisco.

Leonhardt team creates new CerebraCell unit focused on this area called CerebraCell Brain-N-Hance.

2017

Leonhardt and Genovese file new series of patents focused on organ regeneration with combination therapies including brain regeneration.

Dr. Santosh Kesari Director of Research at the Pacific NeuroSciences Institute in Santa Monica, CA joins CerebraCell as Chief Medical & Scientific Advisor.

MIT team reports wireless deep brain stimulation – “Traditional deep brain stimulation requires opening the skull and implanting an electrode, which can have complications. Secondly, only a small number of people can do this kind of neurosurgery,” says Ed Boyden, an associate professor of biological engineering and brain and cognitive sciences at MIT, and the senior author of the study, which appears in the June 1 issue of Cell. CerebraCell team reaches out to them to try to initiate research collaboration.

CerebraCell creates subsidiary CerebraCell Concussion focused on concussion recovery.

Leonhardt files series of patent claims for bioelectric inflammation management including brain inflammation.