For instance, in the United States, TBI is the number one reason for disability for children and young adults from ages 1-44. Currently, 13.5 million Americans live with severe disabilities of TBI, and every year another 2.5 million people sustain a severe brain injury. Additionally, over 50 million Americans are affected each year by one or more of the 600 neurological disorders. Full recovery and even partial recovery for TBI and degenerative diseases remain elusive.
There is an urgent need for improved therapeutic strategies to promote optimal recovery. With the current lack of treatment, our product aims to alleviate suffering for TBI and degenerative disease patients through the latest scientific discovery and product development. CerebraCell is a patented and data-based product available through three different therapeutic approaches depending on the severity of the injury or disease.
non-invasive precise bioelectric stimulation for controlled regenerative protein release
Regenerative Deep Brain Stimulation (DBS)
deep brain stimulation using precise bioelectric stimulation for controlled regenerative protein release
Regenerative DBS and Biologics
deep brain stimulation using precise bioelectric stimulation for controlled regenerative protein release combined with a 15 component full complex brain regeneration composition
Neuroinflammation in traumatic brain injury: A chronic response to an acute injury
Leonhardt MicroStimulator II
Leonhardt Implantable Micro Stimulator Option
Sequenced approach to treatment…
For Stroke, TBI and Concussion…
Time is brain.
CerebraCell In the Field
1. Rapid portable diagnosis.
2. CerebraCell portable one button easy to use non-invasive “Brain Saving Helmet”
Unlocking the Power of Precise Bioelectric Signaling, Stem Cells and Selected Support Agents to Regenerate and Improve Brain Function
Focused on Reversing Damage from Stroke, Traumatic Brain Injury and Concussion and Improving Brain Cognitive Function
Revolutionary Combined Modality Therapeutic Approach
2. Bioelectric stimulation control of stem cell homing, proliferation and differentiation as well as new blood vessel growth and controlled expression of dozens of brain regeneration promoting proteins.
3. Re-fillable micro infusion pump.
4. Fifteen component proprietary CC-15 brain regeneration composition – stem cells, growth factors, exosomes, micro RNAs, selected alkaloids, engineered hydrogels and matrix.
5. Implantable micro implants that communicate with external stimulator generators and EEG analysis.
6. Customized real time bioelectric inflammation modulation and management.
CerebraCell in The Clinic
If the non-invasive “Brain Saving Helmet” after repeat treatments has not restored complete cognitive function then…
2. Implants are connected to micro stimulator and micro pump.
3. Micro stimulator sequences protein expressions SDF-1, IGF-1, HGF, EGF, PDGF, VEGF, eNOS, HIF 1 alpha, Activin A+B, Follistatin, Tropoelastin, GDF-10, GDF-11, stem cell proliferation, stem cell differentiation to brain tissue control and Neurogen 3 to affect brain regeneration.
4. Micro infusion pump is refilled and periodic intervals with stem cell based cocktail mix composition comprised of stem cells, growth factors, amniotic fluid, selected exosomes, selected micro RNAs, selected alkaloids such as harmine, tumeric, engineered hyrogels and brain matrix.
The first to use chronic depth stimulation as a therapy in motor disorders was Natalia Petrovna Bekthereva, neuroscientist at the Institute of Experimental Medicine and the Academy of Medical Sciences in Leningrad. In 1963 she published a work on the use of multiple electrodes implanted in sub-cortical structures for the treatment of hyperkinetic disorders (Bekthereva et al., 1963). However, since her papers were written in Russian, her works were not well known around the world. In her “therapeutic electro-stimulation,” as she named this method, she used “electric stimulation with high-rate pulses of suprathreshold current,” achieving excellent results (Bekthereva et al., 1975).
Leonhardt research team collaborator Dr. Shinichi Kanno publishes in CIRCULATION the Journal of American Heart Association first paper on bioelectric limb regeneration via controlled expression of proteins such as VEGF.
Leonhardt leads team that completes first ever non-surgical stem cell repair of human heart in The Netherlands with Dr. Patrick Serruys. Team went on to complete, publish and present Pilot, Phase I, Phase II and Phase II/III study results working with 33 centers in the USA and 6 centers OUS. 84% of treated patients improved or did not decline. Only 16% of treated patients declined. 69% of control or placebo patients in these same studies worsened in heart function.
Howard Leonhardt and noted bioelectric regeneration research Dr. Jorge Genovese formerly from the University of Utah join forces as co-inventors and begin filing numerous patent application claims together for bioelectric based organ regeneration and recovery.
Dr. Giorgio Lofrese and colleagues in Italy publish on the importance of IGF-1 in brain injury recovery – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568328/
Leonhardt and Genovese filed provisional patent application for bioelectric stimulation controlled release of IGF-1.
Leonhardt’s Launchpads Utah, Inc. with CerebraCell are accepted into the BioInnovations Gateway USTAR laboratory in Utah with access to over $30 million of research lab equipment and resources and subsidized research lab space.
CerebraCell Utah lab team lead by Michael Angerbauer tests out various brain helmet designs for brain stimulation.
Leonhardt and Genovese filed provisional patent application for CerebraCell “Brain Saving Helmet”.
Stanford team (not associated with CerebraCell) led by Dr. Gary Steinberg published landmark study demonstrating remarkable recovery of some brain stroke patients treated with modified stem cells.
CerebraCell announces collaboration with HeartScore to develop a total stroke management program.
CerebraCell presents at Neuro Tech Leaders Forum San Francisco.
Leonhardt team creates new CerebraCell unit focused on this area called CerebraCell Brain-N-Hance.
Leonhardt and Genovese file new series of patents focused on organ regeneration with combination therapies including brain regeneration.
Dr. Santosh Kesari Director of Research at the Pacific NeuroSciences Institute in Santa Monica, CA joins CerebraCell as Chief Medical & Scientific Advisor.
MIT team reports wireless deep brain stimulation – “Traditional deep brain stimulation requires opening the skull and implanting an electrode, which can have complications. Secondly, only a small number of people can do this kind of neurosurgery,” says Ed Boyden, an associate professor of biological engineering and brain and cognitive sciences at MIT, and the senior author of the study, which appears in the June 1 issue of Cell. CerebraCell team reaches out to them to try to initiate research collaboration.
CerebraCell creates subsidiary CerebraCell Concussion focused on concussion recovery.
Leonhardt files series of patent claims for bioelectric inflammation management including brain inflammation.
Howard J. Leonhardt
Executive Chairman & CEO
Dr. Santosh Kesari
Chief Medical Advisor
Dr. Leslie Miller
Chief Medical Officer
Chief MicroPump Engineer
Dr. Thomas Ichim
Chief Stem Cell Scientist
Dr. Stuart K. Williams
VP Biologics Research
Dr. Jorge Genovese
VP Bioelectrics Research
Brittany Brown, CPA
Interim Chief Financial Officer
CTO, VP Engineering and Product Development
Dr. Brett Burton
VP of R&D Utah Lab
Director of Marketing
Staff Neuro Scientist/Grant Writer
VP Business Development and Strategy
Dr. Cristiane Carboni
Leonhardt’s Launchpads Brazil
Catheter Pacing Infusion Lead Engineering Consultant
Business Development Advisor
Business Development Advisor
Dr. Dinesh Patel
Board Director and Senior Advisor
Staff BioEngineer/Grant Writer
Staff BioEngineer/Grant Writer
Dr. Rodrigo Plentz
Lead Clinical Investigator Non-Invasive Stroke Recovery